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The first trucks carrying a COVID-19 vaccine for widespread use in the United States were set to pull out of a Michigan manufacturing plant Sunday, with the shots that are critical to stopping the nation’s coronavirus outbreak destined to reach states a day later.

Shipments of the Pfizer vaccine will set in motion the biggest vaccination effort in American history at a critical juncture of the pandemic that has killed 1.6 million and sickened 71 million worldwide.

Initially, about 3 million doses were expected to be sent out, and the priority is health care workers and nursing home residents as infections, hospitalizations and deaths soar in the U.S. With numbers likely to get worse over the holidays, the vaccine is offering a bright spot in the fight against the pandemic that’s killed nearly 300,000 Americans.

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